解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The published world literature on the efficacy of cimetidine, a histamine H2-receptor antagonist, in the treatment of duodenal ulcer is reviewed. In eight prospective randomized double blind placebo-controlled studies, cimetidine was administered to 348 duodenal ulcer patients with an incidence of endoscopically verif...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1978-02-01 00:00:00
abstract::In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to relatively minor increases in hydrogen ion concentration. All studies became abnormal at pH 6.8. At pH 6.4, assays of the intrinsic and ext...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::To determine the amount of lactose that could be tolerated in a meal, 59 lactase-deficient American Indians, ranging in age from 5 to 62, were given graded doses of lactose. The diagnosis of lactase deficiency had beeen documented previously by showing increased breath hydrogen after an oral lactose load (2 g per kg, ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1978-01-01 00:00:00
abstract::A patient who developed obstructive jaundice as a complication of a liver biopsy is presented. The jaundice was found to be attributable to obstruction of the biliary tree at the level of the bifurcation by an intrahepatic hematoma. The patient had a complete and spontaneous recovery. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::In 6 anesthetized dogs receiving 400 pmoles kg-1 hr-1 of natural human little gastrin intravenously, blood samples for radioimmunoassay of gastrin were taken repeatedly from a carotid artery, jugular vein, femoral vein, renal vein, and mesenteric vein. The calculated removal of gastrin in a single passage through thes...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::A case of primary undifferentiated sarcoma of the liver in a 66-year-old woman is reported. The similarity of the presenting symptoms to those of a hepatic abscess is emphasized. The patient's response to palliative treatment by means of hepatic artery ligation and chemotherapy was excellent. We believe that this is t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::The effect of local intraarterial infusion of arginine vasopressin was studied in a vascularly perfused segment of cat ileum. Systemic arterial pressure (Pa), superior mesenteric arterial pressure (Pma), superior mesenteric venous pressure (Pv), blood flow (QB) and intestinal volume (V) were continuously monitored. In...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract::Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract::There is considerable evidence that fluids are removed from the peritoneal cavity by drainage into lymphatics lining the surface of the diaphragm, but there is little quantitative information on the rate of reabsorption as affected by conditions which exist in cirrhotic ascites. In the present study a plethysmographic...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract::To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract::The hepatic circulation is reviewed with emphasis on the role of hepatic blood vessels in hepatic and homeostatic functions. Contrasts are made with resistance, capacitance, and fluid exchange functions in other better known vascular beds. Hemodynamic changes that produce shifts in fluid exchange in other tissues are ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:1977-11-01 00:00:00
abstract::Raised plasma carcinoembryonic antigen (CEA) levels were found in over 90% of 71 patients with chronic liver disease and 50% of 16 patients with acute liver damage. Levels increasing chronicity and clinical severity of disease. In individual patients, the plasma CEA level fluctuated with the clinical condition. Persis...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::In fed rats, acid production was estimated to be 7 X 10(8) molecules of HCl per cell per sec or 5 X 10(5) molecules per sec per mu2 of secretory surface. In stimulated frog mucosa the corresponding values were 3 X 10(8) molecules of HCl per cell per sec 2 X 10(5) molecules per sec per mu2 or secretory surface. The gen...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::This paper describes the clinical management of 204 patients with Crohn's disease involving the colon who have been reviewed regularly for many years. The results have been analyzed to define the morbidity, mortality, and long term prognosis of the disorder. Despite a high morbidity, the long term prognosis is good. A...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::A 36-year-old man with brittle diabetes mellitus developed hepatic infarction immediately after an episode of ketoacidosis. The infarction was documented by angiogram 99mTc sulfur colloid scan, and biopsy. Except for the association with ketoacidosis, no other possible cause of hepatic infarction was found. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::The acid secretory effect of combined stimulation with balloon distention of the fundus and body of the stomach and intravenous infusion of pentagastrin has been studied in patients with duodenal ulcer (DU) and in healthy subjects. In 8 nonoperated DU subjects and in 5 DU patients subjected to proximal gastric vagotom...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-09-01 00:00:00
abstract::After proximal small bowel resection, the remaining small intestine undergoes adaptive hyperplasia. The role of bile and pancreatic secretions in stimulating ileal mucosal growth after jejunectomy was studied. Male Sprague-Dawley rats were fed either standard rat chow or a liquid elemental diet, and were divided into ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-09-01 00:00:00
abstract::The subcellular localization of intraduodenally administered 59Fe has been studied in control, pregnant, and nonpregnant rats absorbing iron at different rates. Binding of iron to the particulate fractions of mucosal homogenates produced by centrifugation at 500, 10,000, and 100,000 X g did not vary among groups despi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-08-01 00:00:00
abstract::The effect of furosemide on secretin-stimulated pancreatic secretion was examined in 12 normal subjects using a perfusion method to quantitate pancreatic output. During continuous secretin infusion (0.9 U per kg per hr), secretory volume rose to a steady state level of 32.5 +/- 10.2 ml per min. When a bolus injection ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-08-01 00:00:00
abstract::A rapid, sensitive, precise radioimmunoassay for conjugates of chenodeoxycholic (chenic) acid has been developed and validated. Immunogen was prepared with chenylglycine couples to bovine serum albumin, emulsified in Freund's complete adjuvant, and injected intracutaneously in rabbits. Antibodies of moderate titer (us...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-08-01 00:00:00
abstract::To investigate the role of gastric inhibitory polypeptide (GIP), a potent inhibitor of gastric acid secretion, in the hypersecretion associated with duodenal ulcer, we compared the serum GIP concentrations in 11 healthy subjects and 16 duodenal ulcer patients after the stimulation of GIP release by a mixed meal. Fasti...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::Characteristics of a macroamylase that was considered not to be formed by the binding of normal amylase to immunoglobulins were studied. The macroamylase was reversibly dissociated into apparently normal amylase by treating the macroamylasemic serum with guanidine hydrochloride. Concanavalin A precipitated a large por...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::The effect of methacholine, theophylline, and cyclic adenyl and guanyl nucleotides on gastric secretion from antral and proximal duodenal mucosa of the guinea pig was studied. Both 2 mM dibutyryl (db) cAMP and 5 mM theophylline produced significant increases in gastrin secretion, 4.3 +/- 0.7 (P less than 0.001) and 9....
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::The efficacy of phenobarbital in altering biliary lipid composition in normal man was investigated by determining parameters of biliary lipid metabolism in 8 human subjects without biliary tract disease before and after oral phenobarbital administration at a dose of approximately 3 mg per kg per day for 25 to 54 days....
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::A patient with a lifelong history of asthma and hay fever was investigated because of symptoms of esophageal spasm. Esophageal biopsies revealed elongated papillae and basal zone hyperplasia of the epithelial layer with eosinophilic infiltration of the lamina propria and muscularis mucosae. There was no evidence of re...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Basal lower esophageal sphincter (LES) pressure was measured in 6 patients with the Zollinger-Ellison syndrome (ZES) and hypergastrinemia, and in 6 patients with duodenal ulcer and normogastrinemia. Basal LES pressure in ZES patients, 17.0 +/- 3.7 (mean +/- SE) mm Hg was similar to basal LES pressure in duodenal ulcer...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Human gastrointestinal cancer xenografts were established in the nude mouse. Grafts were accomplished with gastric adenocarcinomas, gastric leiomyosarcoma, histiocytic lymphoma of the stomach and gallbladder, pancreatic tumors, colonic cancers and cell lines of duodenal (HUTU-80) and pancreatic (HS-766-T) cancers, mel...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::The effect of experimental bypass on the intestinal epithelium of the rat was investigated from 2 to 360 days after creating a Thiry-Vella fistula. Within 7 to 14 days the number of cells per villus column and, to a lesser degree, the number of cells per crypt column decreased and subsequently these values remained co...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::A technique for the direct measurement of portal vein pressure in fully conscious patients is described. This uses a percutaneous transhepatic approach with a thin Chiba needle and is shown to be simple and safe. The technique has been applied to 123 patients with a variety of liver disorders and the pressure measurem...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::This study was undertaken because of reports of a marked increase in fecal bile acid excretion by children with cystic fibrosis. We attempted to confirm this finding by performing [1-14C]cholylglycine breath tests and by measuring fecal bile acid and fat excretion in patients with cystic fibrosis and acquired pancreat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::Celiac sprue and Crohn's disease have very rarely been documented in the same patient. We report a case involving an adolescent male with known Crohn's disease who had extreme wasting, growth retardation, intractable diarrhea, and delay in development of secondary sexual characteristics. Peroral jejunal biopsy showed ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::Secretin, substance P, and vasoactive intestinal peptide (VIP) were studied from the immunological point of view using synthetic hormones and their related peptides which were prepared by the conventional method for peptide synthesis. Immunological properties of these hormones were characterized by radioimmunoassays s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::Lower esophageal sphincter pressure, basal gastric pH, fasting plasma gastrin, and plasma concentrations of estrone, estradiol, and progesterone were measured in pregnant volunteers at 12, 24, and 36 weeks of gestation, and again at 1 to 4 weeks postpartum. In addition, basal and pentagastrin-stimulated acid secretory...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::Inferior mesenteric arterial blood flow was measured with an electromagnetic blood flowmeter in five anesthetized rhesus monkeys. The effects of vasopressin on this vasculature were determined to evaluate the optimal, safe concentration of this agent during its clinical application in the management of hemorrhagic les...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1-min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::Ethanol (10 or 15% in the drinking water) was found to increase the amount of collagen in the livers of rats receiving a cirrhogenic diet. This effect of ethanol was most striking in the animals receiving 10% ethanol. Ethanol lowered the amount of labeled proline incorporated into hydroxyproline and, therefore, into c...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::Serial studies of plasma lipids and lipoproteins were performed in 4 patients with acute alcoholic liver disease characterized by a massive fatty liver and laboratory evidence of intrahepatic cholestasis. There were striking alterations in the plasma lipoprotein electrophoretic patterns characterized by the absence of...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::Liver disease with inclusions of copper was recognized among 30 rural workers with "vineyard sprayer's lung." The pathological findings were varied: focal or diffuse swelling and proliferation of Kupffer cells; histiocytic and sarcoid-like granulomata; fibrosis of variable degree in the perisinusoidal, portal, and sub...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract::Gastric emptying of a solid meal and serum gastrin concentration were studied in 26 patients with duodenal ulcer disease before and after parietal cell vagotomy (PCV), selective gastric vagotomy with drainage (SGV + D), or parietal cell vagotomy with drainage. PCV had no significant effect on gastric emptying rate, wh...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract::Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is rep...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00